Source: Recombinant genetic engineering production, expressed in Escherichia coli.

一、 Product Introduction

Insulin Icodec is a long-acting human insulin analogue expressed in Escherichia coli through recombinant DNA technology and chemically modified.

Compared to human insulin in terms of structure, it has a threonine at the B30 position of unmanned insulin and introduces C20 fatty acids as side chains. This side of the chain passes through low polyethylene glycol γ- L-glutamic acid (OEG) γ- The L-Glu linker is linked to the lysine at position B29. This change in molecular structure allows Icodec insulin to achieve strong and reversible binding with albumin, significantly prolonging its half-life in vivo, reaching an astonishing 196 hours, and can be administered once a week. In addition, it replaces three amino acids in the human insulin sequence: tyrosine at position A14 is replaced with glutamic acid (A14E), tyrosine at position B16 is replaced with histidine (B16H), and phenylalanine at position B25 is replaced with histidine (B25H). These substitutions reduce their affinity with insulin receptors, thereby reducing insulin receptor binding mediated clearance, while also reducing enzyme degradation and increasing molecular stability.

二、Product features

1、Product source: E.coli

2、Product appearance: White or almost white powder

3、Product purity: ≥ 99%

4、Quality standard: Enterprise standard (in compliance with domestic IND requirements)

5、Storage conditions: Storage and transportation at -15 ℃ and below

6、Validity period: tentatively 24 months

Liquid phase detection spectrum of substances related to the active pharmaceutical ingredient of this product

三、Product advantages

1、Compliant with regulatory requirements: This raw material can be used for scientific research and can also be used for IND declaration in China. For detailed information, please consult our company.

2、Complete quality documents: There is a sound quality assurance system and quality documents.

3、No animal origin: Recombinant production, no external virus contamination, and no use of animal origin raw materials in the production process.

4、Stable quality: mass production can ensure stable and continuous batch production; The difference between product batches is small, and the quality is stable.

四、Related products

Recombinant human insulin, deltamethrin, and aspartic insuli